108708-25-4
Chemical Structure
Z-Pro-Pro-CHO
- CAS No.: 108708-25-4
- Formula:C18H22N2O4
- Molecular Weight:330.38
IUPAC Name: benzyl 2-(2-formylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
InChIKey: ORZXYSPOAVJYRU-UHFFFAOYSA-N
SMILES: O=C(N1C(C(N2C(C=O)CCC2)=O)CCC1)OCC3=CC=CC=C3
Biological Activity: Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC50=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC50=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-Pro-Pro-CHO | 98.03% | Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC50=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC50=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis. | ||||||||||||||||||||
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References
- [1]. Ménoret A, et al. The oxazolidinone derivative locostatin induces cytokine appeasement. J Immunol. 2009;183(11):7489-7496. [Content Brief]
- [2]. Zhu S, et al. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol. 2005;12(9):981-991. [Content Brief]
- [3]. Fajtová P, et al. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015;9(6):e0003827. Published 2015 Jun 3. [Content Brief]
