111753-73-2
Chemical Structure
Satigrel
Synonym(s): E5510
- CAS 番号: 111753-73-2
- Formula:C20H19NO4
- Molecular Weight:337.37
IUPAC Name: 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid
InChIKey: GRVCTHTXJDYIHB-UHFFFAOYSA-N
SMILES: O=C(CC/C(C#N)=C(C1=CC=C(C=C1)OC)/C2=CC=C(C=C2)OC)O
Biological Activity: Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC50: 0.081 μM) and PGHS2 (IC50: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC50: 15.7 μM, 39.8 μM and 62.4 μM, respectively)[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Satigrel | 99.85% | Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC50: 0.081 μM) and PGHS2 (IC50: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC50: 15.7 μM, 39.8 μM and 62.4 μM, respectively). | ||||||||||||||||||||
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