1189657-87-1
1189657-87-1
Chemical Structure
Probenecid-d14
- CAS No.: 1189657-87-1
- Formula:C13H5D14NO4S
- Molecular Weight:299.45
IUPAC Name: 4-(N,N-bis(propyl-d7)sulfamoyl)benzoic acid
InChIKey: DBABZHXKTCFAPX-YTSTUSJFSA-N
SMILES: S(N(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])(=O)(=O)C1=CC=C(C(O)=O)C=C1
Biological Activity: Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].
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Probenecid-d14 | 99.54% | Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels. | ||||||||||||||||||||
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Probenecid (Standard) | 99.29% | Probenecid (Standard) is the analytical standard of Probenecid. This product is intended for research and analytical applications. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels. | ||||||||||||||||||||
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Probenecid-d7 | Probenecid-d7 is deuterium-labeled Probenecid (HY-B0545). | |||||||||||||||||||||
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Probenecid | 99.94% | Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44. [Content Brief]
