1229453-99-9
Chemical Structure
Acrizanib
Synonym(s): LHA510
- CAS No.: 1229453-99-9
- Formula:C20H18F3N7O2
- Molecular Weight:445.40
IUPAC Name: N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide
InChIKey: XPIHPLVWOUDMPF-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC=C(OC3=NC=NC(CNC)=C3)C=C2C=C1)NC4=NN(C)C(C(F)(F)F)=C4
Biological Activity: Acrizanib (LHA510) is a small-molecule vascular endothelial growth factor receptor 2 (VEGFR-2, KDR) inhibitor. Acrizanib inhibits the proliferation of BaF3-Tel-KDR cells dependent on VEGFR-2 activity, with an IC50 of 17.4 nM. Acrizanib can be used in research related to choroidal neovascularization and neovascular age-related macular degeneration[1].
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Acrizanib | 99.84% | Acrizanib (LHA510) is a small-molecule vascular endothelial growth factor receptor 2 (VEGFR-2, KDR) inhibitor. Acrizanib inhibits the proliferation of BaF3-Tel-KDR cells dependent on VEGFR-2 activity, with an IC50 of 17.4 nM. Acrizanib can be used in research related to choroidal neovascularization and neovascular age-related macular degeneration. | ||||||||||||||||||||
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Acrizanib (Standard) | ≥98% | Acrizanib (Standard) (LHA510 (Standard)) is the analytical standard of Acrizanib (HY-109020). This product is intended for research and analytical applications. Acrizanib (LHA510) is a small-molecule vascular endothelial growth factor receptor 2 (VEGFR-2, KDR) inhibitor. Acrizanib inhibits the proliferation of BaF3-Tel-KDR cells dependent on VEGFR-2 activity, with an IC50 of 17.4 nM. Acrizanib can be used in research related to choroidal neovascularization and neovascular age-related macular degeneration. | ||||||||||||||||||||
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Similarity Score 0.53
HY-100419RBFH772 (Standard) -
Similarity Score 0.48
HY-100600BGG463 -
Similarity Score 0.48
HY-132935BPR1R024 -
Similarity Score 0.48
HY-117243GSK329 -
Similarity Score 0.48
HY-15002AST 487 -
Similarity Score 0.47
HY-123714TL4-12 -
Similarity Score 0.47
HY-100394NVP-BAW2881 -
Similarity Score 0.46
HY-164551YLL545 -
Similarity Score 0.46
HY-132935ABPR1R024 mesylate -
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References
- [1]. Adams CM, et al. The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. J Med Chem. 2018 Feb 22;61(4):1622-1635. [Content Brief]
