1229453-99-9
1229453-99-9
Chemical Structure
Acrizanib
Synonym(s): LHA510
- CAS No.: 1229453-99-9
- Formula:C20H18F3N7O2
- Molecular Weight:445.40
IUPAC Name: N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide
InChIKey: XPIHPLVWOUDMPF-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC=C(OC3=NC=NC(CNC)=C3)C=C2C=C1)NC4=NN(C)C(C(F)(F)F)=C4
Biological Activity: Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Acrizanib | 99.84% | Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2. | ||||||||||||||||||||
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Acrizanib (Standard) | ≥98% | Acrizanib (Standard) is the analytical standard of Acrizanib (HY-109020). This product is intended for research and analytical applications. Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2. | ||||||||||||||||||||
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References
- [1]. Adams CM, et al. The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration. J Med Chem. 2018 Feb 22;61(4):1622-1635. [Content Brief]
Keywords
