1309288-83-2
Chemical Structure
KI-DX-014
- CAS No.: 1309288-83-2
- Formula:C17H22N4O3
- Molecular Weight:330.38
IUPAC Name: 3-amino-1-((1-(4-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl)methyl)pyrrolidine-3-carboxylic acid
InChIKey: RYTXGUIGGFFBFX-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)N2N=CC(CN3CCC(C(O)=O)(C3)N)=C2C
Biological Activity: KI-DX-014 is a DDX21 inhibitor with high RNA-binding inhibitory activity (IC50 of 3.31 μM). KI-DX-014 targets DDX21’s intrinsically disordered C-terminal domain, inhibits DDX21-structured RNA interaction, modulates DDX21’s RNA-dependent ATPase activity, and disrupts DDX21 biomolecular condensate formation. KI-DX-014 attenuates in vitro P-TEFb release from the 7SK snRNP complex, suppresses P-TEFb-dependent RNA polymerase II CTD phosphorylation, and induces developmental defects in zebrafish embryos. KI-DX-014 acts as a chemical probe for dissecting DDX21 functions in normal physiology and disease states. KI-DX-014 can be used for cancers and neurodegenerative disorders research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KI-DX-014 | 99.87% | KI-DX-014 is a DDX21 inhibitor with high RNA-binding inhibitory activity (IC50 of 3.31 μM). KI-DX-014 targets DDX21’s intrinsically disordered C-terminal domain, inhibits DDX21-structured RNA interaction, modulates DDX21’s RNA-dependent ATPase activity, and disrupts DDX21 biomolecular condensate formation. KI-DX-014 attenuates in vitro P-TEFb release from the 7SK snRNP complex, suppresses P-TEFb-dependent RNA polymerase II CTD phosphorylation, and induces developmental defects in zebrafish embryos. KI-DX-014 acts as a chemical probe for dissecting DDX21 functions in normal physiology and disease states. KI-DX-014 can be used for cancers and neurodegenerative disorders research. | ||||||||||||||||||||
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Keywords
