134-90-7
Chemical Structure
L-(+)-threo-Chloramphenicol
Synonym(s): (+)-Chloramphenicol; Dextramycine; Dextromycetin
- CAS No.: 134-90-7
- Formula:C11H12Cl2N2O5
- Molecular Weight:323.13
IUPAC Name: 2,2-dichloro-N-((1S,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl)acetamide
InChIKey: WIIZWVCIJKGZOK-IUCAKERBSA-N
SMILES: O=C(C(Cl)Cl)N[C@H]([C@H](C1=CC=C(C=C1)[N+]([O-])=O)O)CO
Biological Activity: L-(+)-threo-Chloramphenicol ((+)-Chloramphenicol) is the S,S-stereoisomer of Chloramphenicol (HY-B0239). L-(+)-Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L-(+)-threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria[1][2].
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L-(+)-threo-Chloramphenicol | L-(+)-threo-Chloramphenicol ((+)-Chloramphenicol) is the S,S-stereoisomer of Chloramphenicol (HY-B0239). L-(+)-Threo-chloramphenicol inhibits protein synthesis in reticulocytes. L-(+)-threo-Chloramphenicol also inhibits the oxidative activity of isolated mitochondria. | |||||||||||||||||||||
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- [1]. 3rd WG, et, al. The effect of chloramphenicol in intact erythroid cells. J Mol Biol. 1966 Nov 28;21(3):537-53. [Content Brief]
- [2]. Gordon PA, et, al. Effects of chloramphenicol isomers and erythromycin on enzyme and lipid synthesis induced by oxygen in wild-type and petite yeast. J Bacteriol. 1972 May;110(2):504-10. [Content Brief]
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