1373615-35-0
1373615-35-0
Chemical Structure
PF-5274857
- CAS. Nr.: 1373615-35-0
- Formula:C20H25ClN4O3S
- Molecular Weight:436.96
IUPAC Name: 1-(4-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one
InChIKey: BBVNTTZIOTWDSV-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O
Biological Activity: PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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PF-5274857 | 99.31% | PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-13459APF-5274857 hydrochloride -
Similarity Score 0.53
HY-153499SMO-IN-4 -
Similarity Score 0.50
HY-164567SID 125240931 -
Similarity Score 0.49
HY-100408RGNF-6231 (Standard) -
Similarity Score 0.48
HY-117240NCT-502 -
Similarity Score 0.46
HY-137502AML267 free base -
Similarity Score 0.46
HY-144734Pantothenate kinase-IN-1 -
Similarity Score 0.45
HY-19960RBCTC (Standard) -
Similarity Score 0.45
HY-18604K-Ras G12C-IN-1 -
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