143445-03-8
Chemical Structure
(rel)-MK 287
Synonym(s): (rel)-L-680573
- CAS No.: 143445-03-8
- Formula:C25H34O9S
- Molecular Weight:510.60
IUPAC Name: 2-((3-methoxy-2-propoxy-5-((2S,5S)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl)phenyl)sulfonyl)ethan-1-ol
InChIKey: WXIDMVGKJBAEFP-OALUTQOASA-N
SMILES: O=S(CCO)(C1=CC([C@H]2O[C@@H](CC2)C3=CC(OC)=C(C(OC)=C3)OC)=CC(OC)=C1OCCC)=O
Biological Activity: (rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis[1].
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(rel)-MK 287 | (rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis. | |||||||||||||||||||||
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Keywords
