1439399-58-2
Chemical Structure
Telaglenastat
Synonym(s): CB-839
- CAS No.: 1439399-58-2
- Formula:C26H24F3N7O3S
- Molecular Weight:571.57
IUPAC Name: 2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide
InChIKey: PRAAPINBUWJLGA-UHFFFAOYSA-N
SMILES: O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
Biological Activity: Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Telaglenastat | 99.82% | Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity. | ||||||||||||||||||||
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Telaglenastat (Standard) | ≥98% | Telaglenastat (Standard) is the analytical standard of Telaglenastat. This product is intended for research and analytical applications. Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity. | ||||||||||||||||||||
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Similarity Score 0.99
HY-12248ATelaglenastat hydrochloride -
Similarity Score 0.80
HY-114334Glutaminase-IN-1 -
Similarity Score 0.77
HY-180241Glutaminase C-IN-3 -
Similarity Score 0.73
HY-79583Glutaminase-IN-3 -
Similarity Score 0.66
HY-146616GLS1 Inhibitor-3 -
Similarity Score 0.58
HY-146658Glutaminase-IN-4 -
Similarity Score 0.56
HY-12683BPTES -
Similarity Score 0.53
HY-152207LWG-301 -
Similarity Score 0.49
HY-157039RIPK1-IN-17 -
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