1492952-76-7
1492952-76-7
Chemical Structure
Asciminib
Synonym(s): ABL001
- CAS No.: 1492952-76-7
- Formula:C20H18ClF2N5O3
- Molecular Weight:449.84
IUPAC Name: (R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)nicotinamide
InChIKey: VOVZXURTCKPRDQ-CQSZACIVSA-N
SMILES: O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4
Biological Activity: Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM[1].
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Asciminib | 99.61% | Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. | ||||||||||||||||||||
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Asciminib (Standard) | 99.63% | Asciminib (Standard) is the analytical standard of Asciminib. This product is intended for research and analytical applications. Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. | ||||||||||||||||||||
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Asciminib-d4 | Asciminib-d4 (ABL001-d4) is the deuterated-labeled Asciminib (HY-104010). Asciminib (ABL001) is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-104010AAsciminib hydrochloride -
Similarity Score 0.89
HY-180982Asciminib-NH2 -
Similarity Score 0.77
HY-136526BCR-ABL-IN-3 -
Similarity Score 0.66
HY-142922BCR-ABL-IN-4 -
Similarity Score 0.50
HY-180968GMB-805 -
Similarity Score 0.50
HY-145887BCR-ABL1-IN-1 -
Similarity Score 0.50
HY-182792Embibatinib -
Similarity Score 0.50
HY-186166(S)-Embibatinib -
Similarity Score 0.49
HY-126429Nav1.1 activator 1 -
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