153-61-7
153-61-7
Chemical Structure
Cephalothin
Synonym(s): Cephalotin
- CAS. Nr.: 153-61-7
- Formula:C16H16N2O6S2
- Molecular Weight:396.44
IUPAC Name: (6R,7R)-3-(acetoxymethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: XIURVHNZVLADCM-IUODEOHRSA-N
SMILES: O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](NC(CC3=CC=CS3)=O)C1=O)O
Biological Activity: Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies[1][2][3][4][5][6][7].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Cephalothin | 99.41% | Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies. | ||||||||||||||||||||
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Cephalothin (Standard) | ≥98% | Cephalothin (Cephalotin) (Standard) is the analytical standard of Cephalothin (HY-B1275A). This product is intended for research and analytical applications. Cephalothin is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies. | ||||||||||||||||||||
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Desacetylcephalothin sodium | Desacetylcephalothin sodium is a metabolite of Cephalothin (HY-B1275A). Desacetylcephalothin sodium exhibits a weak antimicrobial activity. | |||||||||||||||||||||
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Cefaloglycin | 96.06% | Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration. | ||||||||||||||||||||
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Cephalosporin C analog-1 | Cephalosporin C analog-1 is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin. | |||||||||||||||||||||
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Cephalosporin C analog-1 sodium | Cephalosporin C analog-1 sodium is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin. | |||||||||||||||||||||
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Cefaloram | Cefaloram is a cephalosporin antibiotic, but it is inactive against clinical cystic fibrosis isolates of Pseudomonas aeruginosa (MIC50 > 128 μg/mL). | |||||||||||||||||||||
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Cephapirin | 95.57% | Cephapirin (Cefapirin) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity. | ||||||||||||||||||||
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Cefacetrile (Standard) | ≥98% | Cefacetrile (Standard) is the analytical standard of Cefacetrile. This product is intended for research and analytical applications. Cefacetrile (Cephacetrile) is a broad-spectrum antibiotic that is effective in gram-positive and gram-negative bacterial infection. | ||||||||||||||||||||
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Cephalothin sodium (Standard) | ≥98% | Cephalothin (Cephalotin) sodium (Standard) is the analytical standard of Cephalothin sodium (HY-B1275). This product is intended for research and analytical applications. Cephalothin sodium is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin sodium binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin sodium shows antibacterial activity against a variety of bacteria. Cephalothin sodium can be used in hematological and nephrotoxicity studies. | ||||||||||||||||||||
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Cefuracetime (Standard) | ≥98% | Cefuracetime (Standard) (SKF81367 (Standard)) is the analytical standard of Cefuracetime (HY-U00154). This product is intended for research and analytical applications. Cefuracetime is a cephalosporin antibiotic. | ||||||||||||||||||||
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Cefetrizole | Ceftezole is an α-Glucosidase inhibitor with an IC50 and a Ki of 2.1 μM and 0.578 μM, respectively. | |||||||||||||||||||||
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References
- [1]. Morandi S, et al. Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1195-205. Epub 2007 Nov 7. [Content Brief]
- [2]. Desiderio JV, et al. Intraphagocytic killing of Salmonella typhimurium by liposome-encapsulated cephalothin. J Infect Dis. 1983 Sep;148(3):563-70. [Content Brief]
- [3]. Mobashery S, et al. Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters. J Biol Chem. 1986 Jun 15;261(17):7879-87. [Content Brief]
- [4]. Cazenave J-P, et al. Effects of cephalothin and penicillin G on platelet function in vitro. Br J Haematol. 1977 Jan;35(1):135-52. [Content Brief]
- [5]. Miraglia GJ, et al. Comparison of the chemotherapeutic and pharmacodynamic activities of cephradine, cephalothin, and cephaloridine in mice. Antimicrob Agents Chemother. 1973 Feb;3(2):270-3. [Content Brief]
- [6]. Dellinger P, et al. Protective effect of cephalothin against gentamicin-induced nephrotoxicity in rats. Antimicrobial Agents and Chemotherapy, 1976, 9(1): 172-178.
- [7]. Goering RV, et al. Comparison of BL-S786 with cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. J Antibiot (Tokyo). 1978 Apr;31(4):363-72. [Content Brief]
