1541248-45-6
1541248-45-6
Chemical Structure
BMS-159
- CAS No.: 1541248-45-6
- Formula:C22H24ClN10O6P
- Molecular Weight:590.92
InChIKey: ISVBVQAKIIWDLW-RHSMWYFYSA-N
SMILES: N#CC1=CN=C2N1N=C(N=C2NCC)NC3=C(C(N4C[C@H]([C@@H](CC4)NC(OC)=O)OP(O)(O)=O)=CC(C#N)=C3)Cl
Biological Activity: BMS-159 is an orally active, direct phosphate prodrug of BMS-135. BMS-135 is a potent ATP-competitive inhibitor of CK2. BMS-159 can be used in the research of neurological disorders and tumors[1].
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BMS-159 | BMS-159 is an orally active, direct phosphate prodrug of BMS-135. BMS-135 is a potent ATP-competitive inhibitor of CK2. BMS-159 can be used in the research of neurological disorders and tumors. | |||||||||||||||||||||
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References
- [1]. A M Subbaiah M, et al. Enhancing the Oral Bioavailability of a Poorly Soluble Pan-CK2 Kinase Inhibitor: Leveraging a Phosphate Prodrug Strategy to Overcome Dissolution-Limited Absorption and Improve Systemic Exposure during Dose Escalation. J Med Chem. 2026 Jan 22;69(2):1641-1660. [Content Brief]
Keywords
