158093-65-3
158093-65-3
Chemical Structure
PU139
- CAS No.: 158093-65-3
- Formula:C12H7FN2OS
- Molecular Weight:246.26
IUPAC Name: 2-(4-fluorophenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
InChIKey: QMCIVCACYJRAAY-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=C(F)C=C2)SC3=NC=CC=C31
Biological Activity: PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PU139 | 99.51% | PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively. | ||||||||||||||||||||
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References
- [1]. Gajer JM, et al. Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo. Oncogenesis. 2015;4(2):e137. Published 2015 Feb 9. [Content Brief]
- [2]. Carneiro VC, et al. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. PLoS Pathog. 2014;10(5):e1004116. Published 2014 May 8. [Content Brief]
Keywords
