211100-13-9
Chemical Structure
Sabarubicin
Synonym(s): MEN 10755
- CAS No.: 211100-13-9
- Formula:C32H37NO13
- Molecular Weight:643.64
IUPAC Name: (7S,9S)-7-(((2R,4S,5S,6S)-5-(((2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: VQHRZZISQVWPLK-UIRGBLDSSA-N
SMILES: OC1=C2C(C(C3=CC=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)O)N)O)=C1C[C@](O)(C4)C(CO)=O
Biological Activity: Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations.
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Sabarubicin | Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations. | |||||||||||||||||||||
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Keywords
