2200336-20-3
Chemical Structure
Onradivir
Synonym(s): ZSP1273
- CAS No.: 2200336-20-3
- Formula:C22H22F2N6O2
- Molecular Weight:440.45
IUPAC Name: L-serine-2,3,3-d3
InChIKey: JCHDJLSIYWBAHI-ZWHBIUKWSA-N
SMILES: FC1=CN=C2C(C(C3=NC(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=C(F)C(C6CC6)=N3)=NN2)=C1
Biological Activity: Onradivir (ZSP1273) is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC50 of 0.562 nM. Onradivir inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir can be used for the research of influenza A virus infection[1][2].
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Onradivir | 99.53% | Onradivir (ZSP1273) is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC50 of 0.562 nM. Onradivir inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir can be used for the research of influenza A virus infection. | ||||||||||||||||||||
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- [1]. Li J, et al. Onradivir: a novel influenza polymerase inhibitor. Lancet Respir Med. 2025 Jul;13(7):571-573. [Content Brief]
- [2]. Chen X, et al. Preclinical Study of ZSP1273, a Potent Antiviral Inhibitor of Cap Binding to the PB2 Subunit of Influenza A Polymerase. Pharmaceuticals (Basel). 2023;16(3):365. Published 2023 Feb 27. [Content Brief]
Keywords
