220051-79-6
Chemical Structure
AR-A 2
Synonym(s): AR-A 000002
- CAS No.: 220051-79-6
- Formula:C27H36N4O2
- Molecular Weight:448.60
IUPAC Name: (R)-N-(5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl)-4-morpholinobenzamide
InChIKey: IHDRUIHIJWCTIY-JOCHJYFZSA-N
SMILES: CC1=CC=C(N2CCN(C)CC2)C3=C1CC[C@@H](NC(C4=CC=C(N5CCOCC5)C=C4)=O)C3
Biological Activity: AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.
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AR-A 2 | AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety. | |||||||||||||||||||||
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Keywords
