2243575-79-1
2243575-79-1
Chemical Structure
SE-7552
- CAS. Nr.: 2243575-79-1
- Formula:C15H12F3N5O
- Molecular Weight:335.28
InChIKey: JVVZKJQCRUTIMB-UHFFFAOYSA-N
SMILES: FC(F)C(O1)=NN=C1C(C=N2)=CN=C2NC(C)C3=CC=C(F)C=C3
Biological Activity: SE-7552, a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM. SE-7552 is greater than 850-fold selectivity versus all other known HDAC isozymes. SE-7552 is capable of blocking multiple myeloma growth in vivo. SE-7552 acts as an anti-obesity agent in diet-induced obese mice[1][2].
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SE-7552 | 98.79% | SE-7552, a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM. SE-7552 is greater than 850-fold selectivity versus all other known HDAC isozymes. SE-7552 is capable of blocking multiple myeloma growth in vivo. SE-7552 acts as an anti-obesity agent in diet-induced obese mice. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-161304HDAC6-IN-33 -
Similarity Score 0.55
HY-101866KKL-35 -
Similarity Score 0.54
HY-163665AHR antagonist 8 -
Similarity Score 0.54
HY-156107GPR55 agonist 3 -
Similarity Score 0.53
![4,4′-(1,3,4-Oxadiazole-2,5-diyl)bis[benzoic acid] Chemical Structure](//file.medchemexpress.com/product_pic/hy-w586830.gif)
HY-W5868304,4′-(1,3,4-Oxadiazole-2,5-diyl)bis[benzoic acid] -
Similarity Score 0.53
HY-162036α-Amylase/α-Glucosidase-IN-7 -
Similarity Score 0.52
HY-12990Spautin-1 -
Similarity Score 0.52
HY-13696MSX-122 -
Similarity Score 0.52
HY-145270ELOVL1-IN-2 -
Explore the MedChemAI to find more analogs
![4,4′-(1,3,4-Oxadiazole-2,5-diyl)bis[benzoic acid] Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w586830.gif)
References
- [1]. Jason A Holt, et al. SE-7552, a Highly Selective, Non-Hydroxamate Inhibitor of Histone Deacetylase-6 Blocks Multiple Myeloma Growth In Vivo. Blood (2018) 132 (Supplement 1): 3215.
- [2]. Beate König, et al. 2-(Difluoromethyl)-1,3,4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation? ACS Pharmacol. Transl. Sci. 2024, February 20.
