2719691-01-5
2719691-01-5
Chemical Structure
AZ-5104-d2
- CAS No.: 2719691-01-5
- Formula:C27H29D2N7O2
- Molecular Weight:487.59
IUPAC Name: ethyl 6-bromo-4-hydroxyquinoline-8-carboxylate
InChIKey: IQNVEOMHJHBNHC-DICFDUPASA-N
SMILES: O=C(NC1=CC(NC2=NC=CC(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCN(C)C)/C=C([2H])\[2H]
Biological Activity: AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively[1].
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AZ-5104-d2 | AZ-5104-d2 is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC50s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively. | |||||||||||||||||||||
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AZ-5104 | 99.91% | AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively. | ||||||||||||||||||||
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References
Keywords
