2823289-77-4
Chemical Structure
TYRA-200
- CAS No.: 2823289-77-4
- Formula:C23H24FN7O2
- Molecular Weight:449.48
IUPAC Name: N-(1-(5-fluoro-2-((1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3-methyl-1H-indol-5-yl)acrylamide
InChIKey: IMSVRBNZOZXJLS-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC2=C(N(C=C2C)C3=C(C=NC(NC4=CN(N=C4)CC(C)(O)C)=N3)F)C=C1)=O
Biological Activity: TYRA-200 is a potent and orally active FGFR2 inhibitor. TYRA-200 inhibits the kinase activity of wild-type FGFR2 and its mutants. TYRA-200 induces significant tumor regression in FGFR2-driven cancer models. TYRA-200 can be used for the research of FGFR2-altered advanced solid tumors, intrahepatic cholangiocarcinoma, and endometrial cancer[1][2].
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TYRA-200 | 98.06% | TYRA-200 is a potent and orally active FGFR2 inhibitor. TYRA-200 inhibits the kinase activity of wild-type FGFR2 and its mutants. TYRA-200 induces significant tumor regression in FGFR2-driven cancer models. TYRA-200 can be used for the research of FGFR2-altered advanced solid tumors, intrahepatic cholangiocarcinoma, and endometrial cancer. | ||||||||||||||||||||
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- [1]. Rodon Ahnert J, et al. A multicenter, open-label, first-in-human study of TYRA-200 in advanced intrahepatic cholangiocarcinoma and other solid tumors with activating FGFR2 gene alterations (SURF201). J Clin Oncol. 2025;43(4 suppl):TPS646. doi: 10.1200/JCO.2025.43.4.suppl.TPS646
- [2]. Allen E, et al. TYRA-200: Potent Against FGFR2 Fusions, Molecular Brake Mutations and Gatekeeper Resistance. Eur J Cancer. 2022;174 Suppl 1:S16.
Keywords
