284661-68-3
Chemical Structure
DPC-681
Synonym(s): DPH-153893
- CAS No.: 284661-68-3
- Formula:C35H48FN5O5S
- Molecular Weight:669.85
IUPAC Name: (S)-N-((2S,3R)-4-((3-amino-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)-2-(2-((3-fluorobenzyl)amino)acetamido)-3,3-dimethylbutanamide
InChIKey: PNIFFZXGBAYVMQ-RKKDRKJOSA-N
SMILES: O=S(C1=CC(N)=CC=C1)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC([C@H](C(C)(C)C)NC(CNCC3=CC=CC(F)=C3)=O)=O)CC(C)C)=O
Biological Activity: DPC-681 (DPH-153893) is an orally active HIV inhibitor. DPC-681 inhibits HIV protease activity and inhibits wild-type and mutant HIV replication. DPC-681 can be used for the research of HIV infection[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
DPC-681 | 98.80% | DPC-681 (DPH-153893) is an orally active HIV inhibitor. DPC-681 inhibits HIV protease activity and inhibits wild-type and mutant HIV replication. DPC-681 can be used for the research of HIV infection. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.91
HY-171835DPC 684 -
Similarity Score 0.61
HY-150549HIV-1 protease-IN-6 -
Similarity Score 0.58
HY-144688HIV-1 protease-IN-1 -
Similarity Score 0.58
HY-149936HIV-1 protease-IN-8 -
Similarity Score 0.58
HY-155691HIV-1 protease-IN-12 -
Similarity Score 0.57
HY-174998HIV-1 protease-IN-15 -
Similarity Score 0.57
HY-155690HIV-1 protease-IN-11 -
Similarity Score 0.57
HY-17430RAmprenavir (Standard) -
Similarity Score 0.56
HY-147650HIV-1 protease-IN-5 -
Explore the MedChemAI to find more analogs
References
- [1]. Luo G, et al. Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative. Drug Metab Dispos. 2003;31(9):1170-1175. [Content Brief]
- [2]. Kaltenbach RF 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001;45(11):3021-3028. [Content Brief]
