2952-70-7
Chemical Structure
Cyprinol
Synonym(s): 5α-Cyprinol
- CAS No.: 2952-70-7
- Formula:C27H48O5
- Molecular Weight:452.68
IUPAC Name: (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-7-hydroxy-6-(hydroxymethyl)heptan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol
InChIKey: JNMALBXXJSWZQY-BBBUMGABSA-N
SMILES: O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCCC(CO)CO)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]4(C)[C@@](C1)(C[C@H](O)CC4)[H])[H])[H])[H]
Biological Activity: Cyprinol (5α-Cyprinol) is an orally active bile salt and xenochemical pheromone. Cyprinol impairs renal function and increases plasma ALP activity in rats, induces diel vertical migration in Daphnia spp., enhances the permeability of the rectal mucosa to water-soluble compounds, and aids lipid digestion in fish. Cyprinol can be used in studies of fish toxicity and acute renal failure[1][2][3].
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Cyprinol | Cyprinol (5α-Cyprinol) is an orally active bile salt and xenochemical pheromone. Cyprinol impairs renal function and increases plasma ALP activity in rats, induces diel vertical migration in Daphnia spp., enhances the permeability of the rectal mucosa to water-soluble compounds, and aids lipid digestion in fish. Cyprinol can be used in studies of fish toxicity and acute renal failure. | |||||||||||||||||||||
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- [1]. Hwang DF, et al. Identification of cyprinol and cyprinol sulfate from grass carp bile and their toxic effects in rats. Toxicon. 2001;39(2-3):411-414. [Content Brief]
- [2]. Murakami T, et al. Enhancing effect of 5 alpha-cyprinol sulfate on mucosal membrane permeability to sodium ampicillin in rats. Eur J Pharm Biopharm. 2000;49(2):111-117. [Content Brief]
- [3]. Hahn MA, et al. 5α-cyprinol sulfate, a bile salt from fish, induces diel vertical migration in Daphnia. Elife. 2019;8:e44791. Published 2019 May 2. [Content Brief]
Keywords
