3095336-10-7
Chemical Structure
MS7710
- CAS No.: 3095336-10-7
- Formula:C27H36N2O5
- Molecular Weight:468.59
InChIKey: RUYZPWFBOMUDFI-FQEVSTJZSA-N
SMILES: COC1=CC=CC(OCCN2CCC[C@H](CN3C(CC(C=C(OC)C(OC)=C4)=C4CC3)=O)C2)=C1
Biological Activity: MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated Ih current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder[1][2].
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MS7710 | 98.86% | MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated Ih current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder. | ||||||||||||||||||||
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- [1]. Teichman E M. Multimodal Targeting of Neuronal HCN Channels for Antidepressant Drug Discovery[D]. Icahn School of Medicine at Mount Sinai, 2024.
- [2]. Teichman EM, et al. Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype. Mol Psychiatry. 2025;30(9):3937-3950. [Content Brief]
Keywords
