3110370-06-1
Chemical Structure
AH078
- CAS No.: 3110370-06-1
- Formula:C51H60F2N10O5S
- Molecular Weight:963.15
InChIKey: PWYJKWQDDHJXMJ-YKCITUTQSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(CCCCCCC(N2CCC(CN3C(C4=C5C(NC=C5)=NC=C4)=C(C6=NC=C(F)C=C6)N=C3)(F)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Biological Activity: AH078 is a PROTAC-based CK1δ/ε degrader (DC50=0.55 μM, Dmax=70%) that lacks subtype selectivity between CK1δ and CK1ε. AH078 induces target protein degradation either by recruiting the CUL4-CRBN E3 ligase complex and proteasome, or via the VHL- and ubiquitin-dependent pathway. AH078 also exhibits selectivity for CK1α, and is widely applicable to research related to colon cancer, pancreatic cancer, breast cancer, ovarian cancer, chronic lymphocytic leukemia, acute myeloid leukemia, glioma, and metastatic breast adenocarcinoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AH078 | 99.73% | AH078 is a PROTAC-based CK1δ/ε degrader (DC50=0.55 μM, Dmax=70%) that lacks subtype selectivity between CK1δ and CK1ε. AH078 induces target protein degradation either by recruiting the CUL4-CRBN E3 ligase complex and proteasome, or via the VHL- and ubiquitin-dependent pathway. AH078 also exhibits selectivity for CK1α, and is widely applicable to research related to colon cancer, pancreatic cancer, breast cancer, ovarian cancer, chronic lymphocytic leukemia, acute myeloid leukemia, glioma, and metastatic breast adenocarcinoma. | ||||||||||||||||||||
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- [1]. Arnold M, et al. Design and Synthesis of Novel Candidate CK1δ Proteolysis Targeting Chimeras (PROTACs). Molecules. 2025;30(22):4452. Published 2025 Nov 18. [Content Brief]
- [2]. Mikulova A, et al. Casein kinase 1δ/ε inhibition suppresses CLL proliferation through cell‐intrinsic and microenvironmental mechanisms[J]. HemaSphere, 2026, 10(3): e70343.
- [3]. Haag A, et al. Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. J Med Chem. 2025;68(1):506-530. [Content Brief]
Keywords
