3111845-07-6
Chemical Structure
LIBX-A401
- CAS. Nr.: 3111845-07-6
- Formula:C20H21NO4
- Molecular Weight:339.39
InChIKey: OYLZLNPWJRORKJ-JLHYYAGUSA-N
SMILES: CN(CCOC1=CC=C(C=C1)/C=C/C(OC)=O)C(C2=CC=CC=C2)=O
Biological Activity: LIBX-A401 is a selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor with a human IC50 values of 0.38 μM and a Kd of 0.72 μM. LIBX-A401 binds to ACSL4 in an ATP-dependent manner, stabilizes the C-terminal domain, alters the fatty acid gate region, and interacts with residues A329 and Q302 within the fatty acid binding site. LIBX-A401 exhibits anti-ferroptosis properties in cells. LIBX-A401 can be used for the researches of cancer and parkinson's disease[1].
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LIBX-A401 | 99.9% | LIBX-A401 is a selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor with a human IC50 values of 0.38 μM and a Kd of 0.72 μM. LIBX-A401 binds to ACSL4 in an ATP-dependent manner, stabilizes the C-terminal domain, alters the fatty acid gate region, and interacts with residues A329 and Q302 within the fatty acid binding site. LIBX-A401 exhibits anti-ferroptosis properties in cells. LIBX-A401 can be used for the researches of cancer and parkinson's disease. | ||||||||||||||||||||
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