389850-21-9
Chemical Structure
p-nitro-Pifithrin-α
- CAS No.: 389850-21-9
- Formula:C15H16BrN3O3S
- Molecular Weight:398.27
IUPAC Name: 2-(2-imino-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)-1-(4-nitrophenyl)ethan-1-one hydrobromide
InChIKey: NXPCMOGORSWOLH-UHFFFAOYSA-N
SMILES: N=C1SC2=C(CCCC2)N1CC(C3=CC=C([N+]([O-])=O)C=C3)=O.[H]Br
Biological Activity: p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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p-nitro-Pifithrin-α | 97.0% | p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet . non-alcoholic fatty liver disease. | ||||||||||||||||||||
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- [1]. Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am J Nephrol. 2013;37(2):97-103. [Content Brief]
- [2]. Zhang F, et al. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Res. 2016 Oct 14;44(18):8610-8620. [Content Brief]
- [3]. Derdak Z, et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol. 2013 Apr;58(4):785-91. [Content Brief]
Keywords
