41945-48-6
Chemical Structure
Sodium tauroglycocholate
Synonym(s): Tauroglycocholic acid sodium salt
- CAS No.: 41945-48-6
- Formula:C28H47N2NaO8S
- Molecular Weight:594.74
IUPAC Name: sodium 2-(2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)acetamido)ethane-1-sulfonate
InChIKey: PUODKHBECQMSKY-QRPKJZHMSA-M
SMILES: O[C@H](C[C@@](C[C@H](O)CC1)([H])[C@@]1(C)[C@@]2([H])C[C@@H]3O)[C@@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(NCC(NCCS(=O)(O[Na])=O)=O)=O)([H])[C@]34C
Biological Activity: Sodium tauroglycocholate (Tauroglycocholic acid sodium salt) is a multifunctional surfactant and penetration enhancer that can serve as a cholegraphic contrast agent. In organic solvents, Sodium tauroglycocholate embeds and stabilizes invertase by forming reverse micelles, and prolongs its active lifespan. In terms of transdermal absorption, Sodium tauroglycocholate effectively regulates the flux of aminophylline through snake slough by binding to keratin filaments, disrupting keratinocytes and altering lipid components of the stratum corneum. It exhibits rapid penetration characteristics without lag time at a concentration of 100 μg/mL. Sodium tauroglycocholate does not interfere with the hepatic uptake of Gd-EOB-DTPA by the bile acid transport system in rat hepatocytes[1][2][3].
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Sodium tauroglycocholate | 95.0% | Sodium tauroglycocholate (Tauroglycocholic acid sodium salt) is a multifunctional surfactant and penetration enhancer that can serve as a cholegraphic contrast agent. In organic solvents, Sodium tauroglycocholate embeds and stabilizes invertase by forming reverse micelles, and prolongs its active lifespan. In terms of transdermal absorption, Sodium tauroglycocholate effectively regulates the flux of aminophylline through snake slough by binding to keratin filaments, disrupting keratinocytes and altering lipid components of the stratum corneum. It exhibits rapid penetration characteristics without lag time at a concentration of 100 μg/mL. Sodium tauroglycocholate does not interfere with the hepatic uptake of Gd-EOB-DTPA by the bile acid transport system in rat hepatocytes. | ||||||||||||||||||||
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- [1]. Schuhmann-Giampieri G, et al. Biliary excretion and pharmacokinetics of a gadolinium chelate used as a liver-specific contrast agent for magnetic resonance imaging in the rat. J Pharm Sci. 1993;82(8):799-803. [Content Brief]
- [2]. Madamwar D B, et al. Activation and stabilization of invertase entrapped into reversed micelles of sodium lauryl sulfate and sodium tauroglycocholate in organic solvents[J]. Enzyme and microbial technology, 1988, 10(5): 302-305.
- [3]. Kouchak M, et al. Effects of various penetration enhancers on penetration of aminophylline through shed snake skin. Jundishapur J Nat Pharm Prod. 2014;9(1):24-29. [Content Brief]
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