4210-66-6
Chemical Structure
O-Phosphono-L-homoserine
Synonym(s): o-Phosphohomoserine
- CAS No.: 4210-66-6
- Formula:C4H10NO6P
- Molecular Weight:199.10
IUPAC Name: O-phosphono-L-homoserine
InChIKey: FXDNYOANAXWZHG-VKHMYHEASA-N
SMILES: N[C@@H](CCOP(O)(O)=O)C(O)=O
Biological Activity: O-Phosphono-L-homoserine (o-Phosphohomoserine) is an intermediate in threonine synthesis in bacteria and plants, and can also be hijacked by MetM in some Streptomyces species to enter a novel methionine synthesis pathway. O-Phosphono-L-homoserine acts as a weak antagonist of the NMDA receptor. O-Phosphono-L-homoserine can be used as a substrate for studies on amino acid metabolism of the aspartate family, a control for mechanism studies of PLP enzymes, and a reference for structure-activity relationship studies of NMDA receptor ligands[1][2].
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O-Phosphono-L-homoserine | O-Phosphono-L-homoserine (o-Phosphohomoserine) is an intermediate in threonine synthesis in bacteria and plants, and can also be hijacked by MetM in some Streptomyces species to enter a novel methionine synthesis pathway. O-Phosphono-L-homoserine acts as a weak antagonist of the NMDA receptor. O-Phosphono-L-homoserine can be used as a substrate for studies on amino acid metabolism of the aspartate family, a control for mechanism studies of PLP enzymes, and a reference for structure-activity relationship studies of NMDA receptor ligands. | |||||||||||||||||||||
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References
- [1]. Hasebe F, et al. Discovery of a novel methionine biosynthetic route via O-phospho-l-homoserine. Appl Environ Microbiol. 2024;90(10):e0124724. [Content Brief]
- [2]. Connick JH, et al. O-phosphohomoserine, a naturally occurring analogue of phosphonate amino acid antagonists, is an N-methyl-D-aspartate (NMDA) antagonist in rat hippocampus. Neurosci Lett. 1986;68(2):249-251. [Content Brief]
