541-09-3
Chemical Structure
Uranyl acetate
- CAS No.: 541-09-3
- Formula:C4H6O6U
- Molecular Weight:388.11
IUPAC Name: acetoxydioxouranio acetate
InChIKey: MCRZASGCXKHFTN-UHFFFAOYSA-L
SMILES: O=C(O[U](=O)(=O)OC(=O)C)C
Biological Activity: Uranyl acetate is a DNA-binding protein inhibitor that suppresses DNA-binding activity through direct protein-protein interactions. Uranyl acetate stabilizes and fixes DNA and membrane structures in chicken malaria parasite sporozoites via staining. Uranyl acetate induces renal tubular cell apoptosis, regulates the expression of Bcl-2 and Bax, and causes acute renal failure in rats. Uranyl acetate forms stable complexes with ascorbic acid, induces single-strand breaks and relaxation of plasmid DNA in vitro, and exhibits chemical genotoxicity. Uranyl acetate can be used in research related to various diseases such as cancer and acute renal failure[1][2][3][4].
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Uranyl acetate | Uranyl acetate is a DNA-binding protein inhibitor that suppresses DNA-binding activity through direct protein-protein interactions. Uranyl acetate stabilizes and fixes DNA and membrane structures in chicken malaria parasite sporozoites via staining. Uranyl acetate induces renal tubular cell apoptosis, regulates the expression of Bcl-2 and Bax, and causes acute renal failure in rats. Uranyl acetate forms stable complexes with ascorbic acid, induces single-strand breaks and relaxation of plasmid DNA in vitro, and exhibits chemical genotoxicity. Uranyl acetate can be used in research related to various diseases such as cancer and acute renal failure. | |||||||||||||||||||||
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- [1]. Hartsock WJ, et al. Uranyl acetate as a direct inhibitor of DNA-binding proteins. Chemical research in toxicology. 2007 May;20(5):784-9. [Content Brief]
- [2]. Sano K, et al. Role of apoptosis in uranyl acetate-induced acute renal failure and acquired resistance to uranyl acetate. Kidney international. 2000 Apr;57(4):1560-70. [Content Brief]
- [3]. Terzakis JA. Uranyl acetate, a stain and a fixative. Journal of Ultrastructure Research, 1968, 22(1-2):168-184.
- [4]. Yazzie M, et al. Uranyl acetate causes DNA single strand breaks in vitro in the presence of ascorbate (vitamin C). Chemical research in toxicology. 2003 Apr;16(4):524-30. [Content Brief]
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