553-08-2
553-08-2
Chemical Structure
Thonzonium bromide
- CAS No.: 553-08-2
- Formula:C32H55BrN4O
- Molecular Weight:591.71
IUPAC Name: N-(2-((4-methoxybenzyl)(pyrimidin-2-yl)amino)ethyl)-N,N-dimethylhexadecan-1-aminium bromide
InChIKey: WBWDWFZTSDZAIG-UHFFFAOYSA-M
SMILES: CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-]
Biological Activity: Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thonzonium bromide | 99.81% | Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM). | ||||||||||||||||||||
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Thonzonium bromide (Standard) | ≥98% | Thonzonium (bromide) (Standard) is the analytical standard of Thonzonium (bromide). This product is intended for research and analytical applications. Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM). | ||||||||||||||||||||
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Symetine | Symetine is an antiparasitic and antispirochete agent. | |||||||||||||||||||||
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Symetine dihydrochloride | Symetine dihydrochloride (L 16726 dihydrochloride) is the dihydrochloride form of Symetine (HY-101590). Symetine dihydrochloride exhibits antiprotozoal activity aginst Entamoeba histolytica, and ameliorates the amebic liver abscess in guinea pig model. | |||||||||||||||||||||
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Hetramine | Hetramine is a compound with antihistamine and antiallergic activity that prevents histamine-induced intestinal contractions as well as allergy and anaphylactic shock in guinea pigs. | |||||||||||||||||||||
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Benzyldimethylstearylammonium chloride (Standard) | ≥98% | Benzyldimethylstearylammonium chloride (Standard) (BDMSAC (Standard)) is the analytical standard of Benzyldimethylstearylammonium chloride (HY-128443). This product is intended for research and analytical applications. Benzyldimethylstearylammonium chloride is a quaternary ammonium cationic surfactant and a mixed-type corrosion inhibitor. Benzyldimethylstearylammonium chloride adsorbs onto the surface of cold-rolled steel through a combined effect of physisorption and chemisorption, forming a hydrophobic protective barrier that blocks active sites and restricts the diffusion of corrosive media, while simultaneously inhibiting the anodic iron dissolution reaction and the cathodic hydrogen evolution reaction, and reducing the corrosion rate in acidic media. Benzyldimethylstearylammonium chloride is used in research related to various fields such as fungicides, wastewater treatment, and detergents. | ||||||||||||||||||||
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Thonzylamine hydrochloride | Thonzylamine hydrochloride is an orally active H1 histamine receptor antagonist with good antihistaminic and antianaphylactic properties. Thonzylamine hydrochloride can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases. | |||||||||||||||||||||
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Thonzylamine (Standard) | ≥98% | Thonzylamine (Standard) is the analytical standard of Thonzylamine. This product is intended for research and analytical applications. Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases. | ||||||||||||||||||||
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Domiphen bromide (Standard) | ≥98% | Domiphen bromide (Standard) is the analytical standard of Domiphen bromide (HY-B1467). This product is intended for research and analytical applications. Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers. | ||||||||||||||||||||
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Cetalkonium chloride (Standard) | ≥98% | Cetalkonium (chloride) (Standard) is the analytical standard of Cetalkonium (chloride). This product is intended for research and analytical applications. Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death. | ||||||||||||||||||||
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Benzyldimethyltetradecylammonium chloride (Standard) | ≥98% | Benzyldimethyltetradecylammonium (chloride) (Standard) is the analytical standard of Benzyldimethyltetradecylammonium (chloride). This product is intended for research and analytical applications. Benzyldimethyltetradecylammonium chloride is a quaternary ammonium salt consisting of a positively charged N-benzyl-N,N-dimethyltetradecyl-1-amine cation and a negatively charged chloride anion. The compound is commonly used as a surfactant and emulsifier in a variety of applications including detergents, fabric softeners and personal care products. It also has antimicrobial properties and is used as a disinfectant or antiseptic in some products. | ||||||||||||||||||||
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N-(3-Methoxybenzyl)stearamide | 98.04% | N-(3-Methoxybenzyl)stearamide a natural product from Lepidium meyenii (Maca), inhibits human and mouse soluble epoxide hydrolase (hsEH and msEH) with IC50s of 0.001 and <0.001 μg/nM, respectively. | ||||||||||||||||||||
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References
- [1]. Zhu X, et al. Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Biochem Pharmacol. 2016;104:118-130. [Content Brief]
- [2]. Chan CY, et al. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). J Biol Chem. 2012;287(13):10236-10250. [Content Brief]
- [3]. Sims KR, et al. Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery. Nanoscale. 2018;11(1):219-236. [Content Brief]
