1. Anti-infection
    Membrane Transporter/Ion Channel
  2. Bacterial
    Proton Pump
  3. Thonzonium bromide

Thonzonium bromide 

Cat. No.: HY-B1246 Purity: 98.26%
Handling Instructions

Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM).

For research use only. We do not sell to patients.

Thonzonium bromide Chemical Structure

Thonzonium bromide Chemical Structure

CAS No. : 553-08-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 220 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC50=69 μM)[1][2][3].

In Vitro

Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

591.71

Formula

C₃₂H₅₅BrN₄O

CAS No.
SMILES

CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (50.70 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6900 mL 8.4501 mL 16.9002 mL
5 mM 0.3380 mL 1.6900 mL 3.3800 mL
10 mM 0.1690 mL 0.8450 mL 1.6900 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.33%

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Keywords:

ThonzoniumBacterialProton PumpInhibitorinhibitorinhibit

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Thonzonium bromide
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