712313-33-2
Chemical Structure
BayCysLT2
- CAS No.: 712313-33-2
- Formula:C34H39NO8
- Molecular Weight:589.68
IUPAC Name: 3-((3-carboxycyclohexyl)carbamoyl)-4-(3-(4-(4-phenoxybutoxy)phenyl)propoxy)benzoic acid
InChIKey: GKPAULTWHHPIHX-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(OCCCC2=CC=C(C=C2)OCCCCOC3=CC=CC=C3)C(C(NC4CC(C(O)=O)CCC4)=O)=C1)=O
Biological Activity: BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts[1][2].
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BayCysLT2 | BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts. | |||||||||||||||||||||
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References
- [1]. Michael Harter, et al. Isophtalic acid derivatives. US20060154912A1. 2009 March 03.
- [2]. Ni NC, et al. A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. J Pharmacol Exp Ther. 2011 Dec;339(3):768-78. [Content Brief]
