712313-33-2
Chemical Structure
BayCysLT2
- No. CAS: 712313-33-2
- Formula:C34H39NO8
- Molecular Weight:589.68
IUPAC Name: 3-((3-carboxycyclohexyl)carbamoyl)-4-(3-(4-(4-phenoxybutoxy)phenyl)propoxy)benzoic acid
InChIKey: GKPAULTWHHPIHX-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(OCCCC2=CC=C(C=C2)OCCCCOC3=CC=CC=C3)C(C(NC4CC(C(O)=O)CCC4)=O)=C1)=O
Biological Activity: BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BayCysLT2 | 97.7% | BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist with an IC50 value of 53 nM. BayCysLT2 inhibits calcium mobilization induced by leukotriene D4 in HEK293 cells expressing human CysLT2 receptors. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.82
HY-112248(Rac)-HAMI 3379 -
Similarity Score 0.82
HY-112248AHAMI 3379 -
Similarity Score 0.52
HY-112737LY223982 -
Similarity Score 0.50
HY-116045PDEB1-IN-1 -
Similarity Score 0.49
HY-17453RSalmeterol xinafoate (Standard) -
Similarity Score 0.49
HY-11059KH064 -
Similarity Score 0.49
![4,4'-[[2-[(4-Carboxyphenoxy)methyl]-2-ethyl-1,3-propanediyl]bis(oxy)]bis-Benzoic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075669.gif)
HY-W0756694,4'-[[2-[(4-Carboxyphenoxy)methyl]-2-ethyl-1,3-propanediyl]bis(oxy)]bis-Benzoic acid -
Similarity Score 0.49
HY-160901CP-289,503 -
Similarity Score 0.49
HY-112740SC-53228 -
Explore the MedChemAI to find more analogs
![4,4'-[[2-[(4-Carboxyphenoxy)methyl]-2-ethyl-1,3-propanediyl]bis(oxy)]bis-Benzoic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075669.gif)
References
- [1]. Michael Harter, et al. Isophtalic acid derivatives. US20060154912A1. 2009 March 03.
- [2]. Ni NC, et al. A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. J Pharmacol Exp Ther. 2011 Dec;339(3):768-78. [Content Brief]
