778625-65-3
Chemical Structure
MK-0489
- CAS No.: 778625-65-3
- Formula:C34H44ClF2N3O2
- Molecular Weight:600.18
IUPAC Name: N-(2-((R)-1'-((3S,4R)-1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidin]-3-yl)propan-2-yl)acetamide
InChIKey: KMNARKQYUZICHM-ZRRKCSAHSA-N
SMILES: CC(NC(C)([C@@H]1CC2(CCN(C([C@@H]3CN(C(C)(C)C)C[C@H]3C4=CC=C(F)C=C4F)=O)CC2)C5=C1C=C(C)C(Cl)=C5)C)=O
Biological Activity: MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC50 = 13 nM) and functional agonist activity (EC50 = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC50) on mouse MC4R and 1.7 μM (EC50) on mouse MC3R. MK-0489 can be used for the study of obesity[1].
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MK-0489 | MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC50 = 13 nM) and functional agonist activity (EC50 = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC50) on mouse MC4R and 1.7 μM (EC50) on mouse MC3R. MK-0489 can be used for the study of obesity. | |||||||||||||||||||||
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