856242-63-2
856242-63-2
Chemical Structure
MPI8
Synonym(s): TG0205221
- CAS No.: 856242-63-2
- Formula:C32H48N4O7
- Molecular Weight:600.75
InChIKey: YFUZVOLEKQFVCQ-FFXRMZKPSA-N
SMILES: O=C(N[C@H](C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC2CCCCC2)=O)[C@@H](C)OC(C)(C)C)OCC3=CC=CC=C3
Biological Activity: MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19[1][2].
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MPI8 | MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). MPI8 can be used in clinical studies of COVID-19. | |||||||||||||||||||||
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References
- [1]. Ma X R, et al. MPI8 is potent against SARS‐CoV‐2 by inhibiting dually and selectively the SARS‐CoV‐2 main protease and the host cathepsin L[J]. ChemMedChem, 2022, 17(1): e202100456. [Content Brief]
- [2]. Yang S, et al. Synthesis, crystal structure, structure− activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor[J]. Journal of medicinal chemistry, 2006, 49(16): 4971-4980. [Content Brief]
