870964-67-3
870964-67-3
Chemical Structure
Evocalcet
Synonym(s): KHK7580
- CAS No.: 870964-67-3
- Formula:C24H26N2O2
- Molecular Weight:374.48
IUPAC Name: 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic acid
InChIKey: RZNUIYPHQFXBAN-XLIONFOSSA-N
SMILES: O=C(O)CC1=CC=C(N2C[C@@H](N[C@@H](C3=C4C=CC=CC4=CC=C3)C)CC2)C=C1
Biological Activity: Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism[1][2].
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Evocalcet | 99.28% | Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism. | ||||||||||||||||||||
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Evocalcet (Standard) | 98.05% | Evocalcet (Standard) is the analytical standard of Evocalcet. This product is intended for research and analytical applications. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism. | ||||||||||||||||||||
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Evocalcet-d4 | Evocalcet-d4 (KHK7580-d4) is deuterium labeled Evocalcet. Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.69
HY-107773GSK3004774 -
Similarity Score 0.61
HY-103320Calhex 231 -
Similarity Score 0.61
HY-178160SARS-CoV-2 PLpro-IN-2 -
Similarity Score 0.60
HY-103320ARCalhex 231 hydrochloride (Standard) -
Similarity Score 0.58
HY-I0193Cinacalcet impurity 4 -
Similarity Score 0.56
HY-158751Jun9-72-2 -
Similarity Score 0.55
HY-I0577RCinakase impurity 11 (Standard) -
Similarity Score 0.55
HY-W415575Cinacalcet impurity 13 -
Similarity Score 0.55
HY-70037RCinacalcet (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Sakai M, et al. Evocalcet prevents ectopic calcification and parathyroid hyperplasia in rats with secondary hyperparathyroidism. PLoS One. 2020 Apr 28;15(4):e0232428. [Content Brief]
- [2]. Kawata T, et al. A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro. PLoS One. 2018 Apr 3;13(4):e0195316. [Content Brief]
