891509-95-8
Chemical Structure
SR-4995
Synonym(s): CID 16016685
- CAS No.: 891509-95-8
- Formula:C19H21N3O2S
- Molecular Weight:355.45
IUPAC Name: 1-butyl-3-(10-methyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-8-yl)urea
InChIKey: UGYXUEPBYOKNOL-UHFFFAOYSA-N
SMILES: O=C1N(C)C2=C(C=CC(NC(NCCCC)=O)=C2)SC3=CC=CC=C31
Biological Activity: SR-4995 (CID 16016685) is a highly effective and selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways.
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SR-4995 | 98.26% | SR-4995 (CID 16016685) is a highly effective and selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways. | ||||||||||||||||||||
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Keywords
