Art. -Nr.: HY-113162

Bovinic acid

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Bovinic acid is an orally active anti-inflammatory agent. Bovinic acid inhibits oxidative stress and ferroptosis by regulating the Keap1-Nrf2 signaling pathway. Bovinic acid exerts hepatoprotective effects against alcohol-associated liver disease. Bovinic acid can be used for the research of alcohol-associated liver disease.

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Reinheit: 96.21%
CAS. Nr.: 2540-56-9
Formel: C₁₈H₃₂O₂
Molecular Weight:280.45

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Bovinic acid Chemical Structure

CAS. Nr.: 2540-56-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Bovinic acid (0.5-50 μM) inhibits oxidative stress and ferroptosis in HepG2 cells treated with ethanol/tBHP (reducing the levels of ROS, MDA, and Fe²⁺, and enhancing the activities of SOD and GSH)^[1].
Bovinic acid activates the Keap1-Nrf2 antioxidant signaling pathway in ethanol/tBHP-treated HepG2 cells by downregulating Keap1 and upregulating Nrf2 and HMOX1^[1].
Bovinic acid inhibits TFRC-mediated iron uptake in ethanol/tBHP-treated HepG2 cells by downregulating TFRC mRNA expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bovinic acid (0.1 g/kg; i.g.; daily; 10 days) alleviates ethanol-induced alcohol-related liver disease in male C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8 weeks old, alcohol-associated liver disease model)^[1]
Dosage:

0.1 g/kg
Administration:

i.g.; daily; 10 days
Result:

Significantly reduced elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.
Increased hepatic superoxide dismutase (SOD) activity.
Decreased hepatic malondialdehyde (MDA) levels.
Reduced hepatic Fe²⁺ levels.
Improved liver parenchymal morphology and reduced hepatic inflammation (H&E staining).

Chemical Information

CAS. Nr. 2540-56-9
Appearance Liquid (Density: 0.911±0.06 g/cm³)
Molecular Weight 280.45
Formel C₁₈H₃₂O₂
Color Colorless to light yellow
SMILES

CCCCCC/C=C/C=C\CCCCCCCC(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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J Anal Test

2024 Dec.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (356.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5657 mL

17.8285 mL

35.6570 mL

5 mM

0.7131 mL

3.5657 mL

7.1314 mL

10 mM

0.3566 mL

1.7828 mL

3.5657 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (8.91 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 20 mg/mL (71.31 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dong Z, et al. Pien Tze Huang ameliorates alcohol-associated liver disease by suppressing oxidative stress and ferroptosis through bovinic acid and taurine.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5657 mL	17.8285 mL	35.6570 mL	89.1424 mL
	5 mM	0.7131 mL	3.5657 mL	7.1314 mL	17.8285 mL
	10 mM	0.3566 mL	1.7828 mL	3.5657 mL	8.9142 mL
	15 mM	0.2377 mL	1.1886 mL	2.3771 mL	5.9428 mL
	20 mM	0.1783 mL	0.8914 mL	1.7828 mL	4.4571 mL
	25 mM	0.1426 mL	0.7131 mL	1.4263 mL	3.5657 mL
	30 mM	0.1189 mL	0.5943 mL	1.1886 mL	2.9714 mL
	40 mM	0.0891 mL	0.4457 mL	0.8914 mL	2.2286 mL
	50 mM	0.0713 mL	0.3566 mL	0.7131 mL	1.7828 mL
	60 mM	0.0594 mL	0.2971 mL	0.5943 mL	1.4857 mL
	80 mM	0.0446 mL	0.2229 mL	0.4457 mL	1.1143 mL
	100 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.8914 mL

Keywords

Bovinic acid

1 Cited Publications

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Bovinic acid

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Publications Citing Use of MedChemExpress (MCE) Bovinic acid

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bovinic acid Related Classifications

HY-113162 Related Classifications