Wnt1
Wnt1 is a secreted Wnt ligand that mediates signaling through Frizzled/LRP5/6 and the β-catenin-dependent canonical Wnt pathway, a pathway linked to cell proliferation and differentiation[1]. Mechanistically, Wnt1 has essential developmental relevance because Wnt1- mice lose the midbrain and adjacent cerebellar component, showing its requirement for midbrain-hindbrain development[2][3]. In disease-focused skeletal research, WNT1 mutations cause early-onset osteoporosis and osteogenesis imperfecta, identifying WNT1 as a key ligand regulating human bone mass[4][5]. Wnt1 mutant mouse models reproduce bone fragility and support experimental analysis of osteogenesis imperfecta mechanisms[6]. Compared with Wnt5a, which can antagonize canonical Wnt signaling by promoting β-catenin degradation, Wnt1 is best positioned as a canonical Wnt ligand for β-catenin-centered experimental design[1][7]. For applied studies, Wnt1-Cre models remain useful for neural crest and midbrain research, but developmental phenotypes from ectopic Wnt signaling require careful controls[8]. Wnt-pathway inhibitors such as PORCN inhibitors can block Wnt ligand processing and secretion, providing tools to test Wnt-ligand-dependent signaling in Wnt-driven models[9].
Verweise:
- [1]. Qin K, et al. Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk. Genes Dis. 2023 Mar 24;11(1):103-134. [Content Brief]
- [2]. McMahon AP, et al. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell. 1990 Sep 21;62(6):1073-85. [Content Brief]
- [3]. McMahon AP, et al. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell. 1992 May 15;69(4):581-95. [Content Brief]
- [4]. Laine CM, et al. WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N Engl J Med. 2013 May 9;368(19):1809-16. [Content Brief]
- [5]. Keupp K, et al. Mutations in WNT1 cause different forms of bone fragility. Am J Hum Genet. 2013 Apr 4;92(4):565-74. [Content Brief]
- [6]. Vollersen N, et al. The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV. Bone Res. 2021 Nov 10;9(1):48. [Content Brief]
- [7]. Topol L, et al. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol. 2003 Sep 1;162(5):899-908. [Content Brief]
- [8]. Lewis AE, et al. The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15;379(2):229-34. [Content Brief]
- [9]. Liu J, et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9. [Content Brief]
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Wnt1 Verwandte Produkte (2)
Verwandte Produkte (2)
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SJ26
0 ImagesSJ26 is a Wnt1 inhibitor with anticancer activity. SJ26 inhibits the expression of Wnt1 and Wnt1-mediated downstream signaling pathways in a G-quadruplex structure-dependent manner to suppress the migration activity of cancer cells.
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CM002
0 ImagesArt. -Nr.: HY-184895CM002 is a circadian clock activator. CM002 inhibits the lineage commitment and terminal differentiation of preadipocytes by activating the circadian clock, thereby blocking the adipogenesis process driven by Wnt signaling-mediated transcriptional induction. CM002 attenuates lipid storage in a clock-dependent manner via inhibition of the lipogenic program in mature adipocytes. CM002 enhances circadian clock output across various adipose depots in both lean and obese mice through BMAL1/CLOCK-dependent metabolic reprogramming, inhibits adipocyte development and hypertrophy, and improves insulin sensitivity. CM002 can be used in research on obesity and type 2 diabetes.
