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Art. -Nr.: HY-152201

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BTK-IN-18

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC₅₀ of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo.

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CAS. Nr.: 1374239-71-0
Formel: C₂₀H₂₂Cl₂N₆O
Molecular Weight:433.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

BTK-IN-18 Chemical Structure

CAS. Nr.: 1374239-71-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC₅₀ of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	0.025 μM Compound: 41	Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4 Inhibition of B cell proliferation in PBMC (unknown origin) in the presence of anti-IgM and IL-4	[PMID: 36538993]
B-cell	IC₅₀	0.05 μM Compound: 41	Inhibition of B cell proliferation in PBMC (unknown origin) Inhibition of B cell proliferation in PBMC (unknown origin)	[PMID: 36538993]

In Vivo

BTK-IN-18 (compound 41; 10, 25, 45 mg/kg; IP; single dose) causes robust dose-dependent inhibition of both CD69 and CD86^[1].
BTK-IN-18 (iv; 1 mg/kg) has a T_1/2 of 5.3 hours, a CL of 19 mL/min/kg, and a V_ss of 1.3 L/kg for rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[1]
Dosage:

10, 25, 45 mg/kg
Administration:

IP; single dose
Result:

Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively).

Animal Model:
Dosage:
Administration:

Result:

Pharmacokinetic Parameters of BTK-IN-18 in rats^[1].

	IV (1 mg/kg)	PO (5 mg/kg)
T_max (h)		1.6
C_max (h∗mg/mL)	321
AUC_infi (h∗mg/mL)	1013	1421
t_1/2 (ng/mL)	5.3
CL (mL/min/kg)	19
V_ss (L/kg)	1.3
F (%)	23%

Chemical Information

CAS. Nr. 1374239-71-0
Molecular Weight 433.33
Formel C₂₀H₂₂Cl₂N₆O
SMILES

C[C@@H]1[C@@H](CCCN1C(CNC2=CC(Cl)=CC(Cl)=C2)=O)NC3=C4C=CNC4=NC=N3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. George H Vandeveer, et al. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model. Bioorg Med Chem Lett. 2022 Dec 17;80:129108. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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