381683-92-7
381683-92-7
Chemical Structure
Ecopladib
Synonym(s): PLA 725
- CAS. Nr.: 381683-92-7
- Formula:C39H33Cl3N2O5S
- Molecular Weight:748.11
IUPAC Name: 4-(2-(1-benzhydryl-5-chloro-2-(2-(((3,4-dichlorophenyl)methyl)sulfonamido)ethyl)-1H-indol-3-yl)ethoxy)benzoic acid
InChIKey: FMMCHWHNSUBYAV-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(OCCC2=C(CCNS(=O)(CC3=CC=C(Cl)C(Cl)=C3)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)C=C1
Biological Activity: Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.
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Ecopladib | Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively. | |||||||||||||||||||||
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Keywords
