57159-62-3
57159-62-3
Chemical Structure
N-Succinimidyl 3-(Bromoacetamido)propionate
Synonym(s): 3-(2-Bromoacetamido)propanoic acid NHS ester
- CAS. Nr.: 57159-62-3
- Formula:C9H11BrN2O5
- Molecular Weight:307.10
IUPAC Name: 2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate
InChIKey: WGMMKWFUXPMTRW-UHFFFAOYSA-N
SMILES: O=C(ON1C(CCC1=O)=O)CCNC(CBr)=O
Biological Activity: N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
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N-Succinimidyl 3-(Bromoacetamido)propionate | N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). | |||||||||||||||||||||
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References
- [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
- [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]
