OSBPL6 - oxysterol binding protein like 6 Gene

Also Known as ORP6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114880

About OSBPL6

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,193,774-178,402,893 (from NCBI)

This gene has 9 transcripts (splice variants), 219 orthologues and 11 paralogues. Broad expression in brain (RPKM 4.0), skin (RPKM 2.6) and 21 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

OSBPL6 Products (5)

mRNA Protein Name
NM_001201480.2 NP_001188409.1 oxysterol-binding protein-related protein 6 isoform c
NM_001201481.2 NP_001188410.1 oxysterol-binding protein-related protein 6 isoform d
NM_001201482.2 NP_001188411.1 oxysterol-binding protein-related protein 6 isoform e
NM_032523.4 NP_115912.1 oxysterol-binding protein-related protein 6 isoform a
NM_145739.3 NP_665682.1 oxysterol-binding protein-related protein 6 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in regulation of cholesterol transport IMP
IMP: Inferred from mutant phenotype
26941018 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytosol IDA
IDA: Inferred from direct assay
14593528 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
26941018 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
26941018 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
14593528 GOA
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
14593528 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14593528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL6 Protein Structure

PH_8

PH_8: Pleckstrin homology domain (91 - 178)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (570 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 934 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein-related protein 6

  • ORP-6

OSBPL6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
OSBPL6 Q9BZF3 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rhizomelic Chondrodysplasia Punctata, Type 3

  • Rhizomelic Chondrodysplasia Punctata Type 3

  • RCDP3

  • Alkyldihydroxyacetonephosphate Synthase Deficiency

  • Alkylglycerone-Phosphate Synthase Deficiency

  • Agps Deficiency

  • Rhizomelic Chondrodysplasia Punctata 3

  • Chondrodysplasia Punctata, Rhizomelic, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09843 OSBPL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris OSBPL6 VGNC VGNC:44156
Macaca mulatta OSBPL6 VGNC VGNC:75627
Bos taurus OSBPL6 VGNC VGNC:32464
Rattus norvegicus OSBPL6 RGD RGD:1308887
Felis catus OSBPL6 VGNC VGNC:63981
Mus musculus OSBPL6 MGD MGI:2139014
Others OSBPL6 NCBI