LIPI - lipase I Gene

Also Known as CT17; LPDL; PLA1C; PRED5; mPA-PLA1 beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 149998

About LIPI

Cytogenetic location: 21q11.2 Genomic coordinates (GRCh38): 21:14,108,812-14,210,955 (from NCBI)

This gene has 8 transcripts (splice variants), 286 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in thyroid (RPKM 1.4), endometrium (RPKM 0.3) and 2 other tissues.

Summary

The protein encoded by this gene is a Phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

LIPI Products (7)

mRNA	Protein	Name
NM_001302998.2	NP_001289927.1	lipase member I isoform 1 precursor
NM_001302999.2	NP_001289928.1	lipase member I isoform 2
NM_001303000.2	NP_001289929.1	lipase member I isoform 3 precursor
NM_001303001.2	NP_001289930.1	lipase member I isoform 4
NM_001379565.1	NP_001366494.1	lipase member I isoform 6
NM_001379566.1	NP_001366495.1	lipase member I isoform 7 precursor
NM_198996.4	NP_945347.3	lipase member I isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables heparin binding	IDA IDA: Inferred from direct assay	12963729	GOA
enables phospholipase activity	IDA IDA: Inferred from direct assay	12963729	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in lipid catabolic process	IDA IDA: Inferred from direct assay	12963729	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12963729	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12963729	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIPI Protein Structure

Lipase

0
100
200
300
400
481 a.a.

Protein Preferred Names	Protein Names
lipase member I	LPD lipase

Related Diseases

Diseases	Alias
Hypertriglyceridemia 1	Hypertriglyceridemia Hypertriglyceridemia, Familial Hypertriglyceridemia, Susceptibility To HYTG1 FHTR Hypertriglyceridemias Familial
Posterior Cerebral Artery Infarction	Infarction, Posterior Cerebral Artery
Diffuse Pulmonary Fibrosis
Developmental And Epileptic Encephalopathy 53	DEE53 Epileptic Encephalopathy, Early Infantile, 53 Eiee53 Developmental And Epileptic Encephalopathy, 53 Early Infantile Epileptic Encephalopathy 53
Ciliary Dyskinesia, Primary, 26	Primary Ciliary Dyskinesia 26 CILD26 Primary Ciliary Dyskinesia 26 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 26, With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, 26
Ewing Sarcoma Of Bone	Ewing'S Sarcoma Of Bone Bone Ewing Sarcoma Bone Ewing'S Sarcoma Bone Localized Ewing Sarcoma Bone Localized Ewing'S Sarcoma Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor Localized Skeletal Ewing'S Sarcoma Localized Bone Ewing Sarcoma
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07691	LIPI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18483	Lipi Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24965	Lipi Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LIPI	VGNC	VGNC:42698
Rattus norvegicus	LIPI	RGD	RGD:1310162
Felis catus	LIPI	VGNC	VGNC:63240
Mus musculus	LIPI	MGD	MGI:2443868
Others	LIPI	NCBI