COPS9 - COP9 signalosome subunit 9 Gene

Also Known as CSNAP; MYEOV2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 150678

About COPS9

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,126,548-240,136,347 (from NCBI)

This gene has 5 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in brain (RPKM 12.9), fat (RPKM 12.7) and 25 other tissues.

Summary

Involved in several processes, including cellular response to UV; cytoplasmic sequestering of protein; and negative regulation of protein neddylation. Located in chromatin; cytoplasm; and nucleoplasm. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

COPS9 Products (2)

mRNA Protein Name
NM_001163424.2 NP_001156896.1 COP9 signalosome complex subunit 9 isoform 2
NM_138336.1 NP_612209.1 COP9 signalosome complex subunit 9 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
23776465 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to UV IDA
IDA: Inferred from direct assay
26456823 GOA
involved in cytoplasmic sequestering of protein IMP
IMP: Inferred from mutant phenotype
23776465 GOA
involved in negative regulation of protein neddylation IMP
IMP: Inferred from mutant phenotype
23776465 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
26456823 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
23776465 GOA
located in chromatin IDA
IDA: Inferred from direct assay
26456823 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
26456823 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
23776465 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26456823 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS9 Protein Structure

MYEOV2

MYEOV2: Myeloma-overexpressed-like (1 - 56)

  • 0
  • 57 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 9

  • CSN acidic protein

Related Diseases

Diseases Alias
Photoparoxysmal Response 1

  • Photosensitivity Disease

  • Photodermatitis

  • Photosensitivity Disorders

  • PPR1

  • Ppr

  • Photosensitivity

  • Photoconvulsive Reaction

  • Epilepsy, Photogenic

  • Photosensitivity Of Skin

  • Dermatitis, Phototoxic
Balo Concentric Sclerosis

  • Balo'S Concentric Sclerosis

  • Balo Disease

  • Diffuse Cerebral Sclerosis Of Schilder

  • Tumefactive Multiple Sclerosis

  • Concentric Demyelination

  • Balo'S Disease

  • Baló Concentric Sclerosis

  • Encephalitis Periaxialis Concentrica

  • Marburg Variant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03033 COPS9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COPS9 RGD RGD:1596701
Mus musculus COPS9 MGD MGI:1914165
Bos taurus COPS9 VGNC VGNC:54910
Others COPS9 NCBI