ZFPM1 - zinc finger protein, FOG family member 1 Gene

Also Known as FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 161882

About ZFPM1

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,451,769-88,537,031 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues and 1 paralogue. Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

ZFPM1 Products (1)

mRNA	Protein	Name
NM_153813.3	NP_722520.2	zinc finger protein ZFPM1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11675338	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12483298	GOA
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	15920471	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	21646796	GOA
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15920471	GOA
involved in platelet formation	IGI IGI: Inferred from genetic interaction	11675338	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	21646796	GOA
involved in regulation of definitive erythrocyte differentiation	IDA IDA: Inferred from direct assay	15920471	GOA
involved in regulation of definitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17207461	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15920471	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	15920471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFPM1 Protein Structure

zf-C2H2_6

zf-H2C2_2

zf-C2H2_6

0
200
400
600
800
1006 a.a.

Protein Preferred Names	Protein Names
zinc finger protein ZFPM1	FOG-1

ZFPM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ZFPM1	Q8IX07	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	21988832
Intra	ZFPM1	Q8IX07	RBBP4	Homo sapiens	Q09028	Pull Down	21047798

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Thrombocytopenia 1	Xlt THC1 Thrombocytopenia, X-Linked Thrombocytopenia, X-Linked, Intermittent X-Linked Thrombocytopenia X-Linked Thrombocytopenia With Normal Platelets Thc Thrombocytopenia, X-Linked, 1 Thrombocytopenia X-Linked Thrombocytopenia X-Linked 1
Congenital Dyserythropoietic Anemia	Congenital Dyshaematopoietic Anaemia Dyserythropoietic Anemia, Congenital Cda Anemia, Dyserythropoietic, Congenital Anemia Dyserythropoietic Congenital Cda - [Congenital Dyserythropoietic Anaemia] Dyserythropoietic Dyshaematopoietic Congenital Anaemia Dyshaematopoietic Anaemia Dyserythropoietic Anaemia
Thrombocytopenia With Beta-Thalassemia, X-Linked	XLTT Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome Gata1-Related X-Linked Cytopenia X-Linked Thrombocytopenia With Beta-Thalassemia Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Retinitis Pigmentosa 56	RP56 Maculopathy, Impg2-Related MACLP-IMPG2 Retinitis Pigmentosa, Type 56
Cutaneous Porphyria	Porphyria, Erythropoietic Erythropoietic Porphyria
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Persistent Hyperplastic Primary Vitreous	Congenital Retinal Detachment Ncrna Disease Non-Syndromic Congenital Retinal Non-Attachment Pfvs Phpv Persistent Fetal Vasculature Syndrome
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS16048	ZFPM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19759	Zfpm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26256	Zfpm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZFPM1	VGNC	VGNC:53486
Mus musculus	ZFPM1	MGD	MGI:1095400
Bos taurus	ZFPM1	VGNC	VGNC:58429
Rattus norvegicus	ZFPM1	RGD	RGD:1582810
Macaca mulatta	ZFPM1	VGNC	VGNC:104765
Others	ZFPM1	NCBI