EPHB6 - EPH receptor B6 Gene

Also Known as HEP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2051

About EPHB6

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:142,855,076-142,871,093 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 124 orthologues and 53 paralogues. Biased expression in skin (RPKM 52.0), brain (RPKM 17.5) and 11 other tissues.

Summary

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike Other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

EPHB6 Products (3)

mRNA Protein Name
NM_001280794.3 NP_001267723.2 ephrin type-B receptor 6 isoform b
NM_001280795.2 NP_001267724.2 ephrin type-B receptor 6 isoform b
NM_004445.6 NP_004436.4 ephrin type-B receptor 6 isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHB6 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (33 - 232)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (304 - 339)

fn3

fn3: Fibronectin type III domain (371 - 467)

fn3

fn3: Fibronectin type III domain (492 - 571)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (595 - 667)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (670 - 913)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (948 - 1010)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1021 a.a.
Protein Preferred Names Protein Names

ephrin type-B receptor 6

  • human kinase-defective Eph-family receptor protein

EPHB6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
EPHB6 O15197 HSP90AB1 Homo sapiens P08238
BioID
35384245
Intra
EPHB6 O15197 HSP90AB1 Homo sapiens P08238
Affinity Chrom
35384245
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHB6 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75751 EphB6 Protein, Human (HEK293) O15197-1 (L32-S594) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75752 EphB6 Protein, Human (HEK293, Fc) O15197-1 (L32-S594) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75753 EphB6 Protein, Human (HEK293, His) O15197-1 (L32-S594) ≥ 90%, as determined by reducing SDS-PAGE.

EPHB6 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83827 EphB6 Antibody (YA3524) WB, IHC-P, ELISA Human
HY-P83827A EphB6 Antibody (YA3524)(PBS only) WB, IHC-P, ELISA Human
HY-P85149 EphB6 Antibody (YA4841) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Good Syndrome

  • Immunodeficiency With Thymoma

  • Thymoma-Immunodeficiency Syndrome

  • Thymoma With Hypogammaglobulinemia

  • Thymoma Immunodeficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-148066 DB0662 Degrader 99.66% Unkown
HY-RS04437 EPHB6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18386 Ephb6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24867 Ephb6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EPHB6 VGNC VGNC:61909
Macaca mulatta EPHB6 VGNC VGNC:72244
Bos taurus EPHB6 VGNC VGNC:107222
Rattus norvegicus EPHB6 RGD RGD:1306163
Mus musculus EPHB6 MGD MGI:1096338
Canis familiaris EPHB6 VGNC VGNC:40414
Others EPHB6 NCBI