EphB6 Antibody (YA4841)
(Synonyms: EPHB6; Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6)EphB6 Antibody (YA4841) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to EphB6.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
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| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 | 1:50-200 |
Product Details
EphB6 Antibody (YA4841) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to EphB6.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 111 kDa;
Purified recombinant fragment of EphB6 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EphB6 is a Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2
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Subcellular Localization
Membrane; Single-pass type I membrane protein; Secreted
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Expression
Tissue_specificity:Expressed in brain tissue. Expressed in non-invasive breast cancer cell lines (protein level) . Strongly expressed in the brain and pancreas, and weakly expressed in other tissues such as the heart, placenta, lung, liver, skeletal muscle, and kidney. Expressed in non-invasive breast tumors, but not in metastatic lesions. Isomer 3 is expressed in cell lines of glioblastoma, anaplastic astrocytoma, gliosarcoma, and astrocytoma. Isomer 3 was not detected in normal tissues. -
Isoforms & Post-Translational Modification
O15197 has 3 isomers: O15197-1: 110700 Da (predicted); O15197-2: 81211 Da (predicted); O15197-3: 57498 Da (predicted).
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion -
Subunit
Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner
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SwissProt ID
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Synonyms
EPHB6; Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6
Documentation
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