2. Gene
  3. EPHB6 - EPH receptor B6 Gene

EPHB6 - EPH receptor B6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEP

Gene ID: 2051 | Gene type: protein coding

About EPHB6

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:142,855,076-142,871,093 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 124 orthologues and 53 paralogues. Biased expression in skin (RPKM 52.0), brain (RPKM 17.5) and 11 other tissues.

Summary

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

EPHB6 Products(3)

mRNA Protein Name
NM_001280794.3 NP_001267723.2 ephrin type-B receptor 6 isoform b
NM_001280795.2 NP_001267724.2 ephrin type-B receptor 6 isoform b
NM_004445.6 NP_004436.4 ephrin type-B receptor 6 isoform a precursor

EPHB6 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (33 - 232)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (304 - 339)

fn3

fn3: Fibronectin type III domain (371 - 467)

fn3

fn3: Fibronectin type III domain (492 - 571)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (595 - 667)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (670 - 913)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (948 - 1010)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1021 a.a.
Protein Preferred Names Protein Names

ephrin type-B receptor 6

human kinase-defective Eph-family receptor protein

Recombinant EPHB6 Proteins

Cat. No. Product Name Accession Purity
HY-P75751 EphB6 Protein, Human (HEK293) O15197 (L32-S594) ≥95%
HY-P75752 EphB6 Protein, Human (HEK293, Fc) O15197 (L32-S594) ≥95%
HY-P75753 EphB6 Protein, Human (HEK293, His) O15197 (L32-S594) ≥95%

Related Diseases

Diseases Alias
Good Syndrome

Immunodeficiency With Thymoma

Thymoma-Immunodeficiency Syndrome

Thymoma With Hypogammaglobulinemia

Thymoma Immunodeficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04437 EPHB6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EPHB6 VGNC VGNC:61909
Macaca mulatta EPHB6 VGNC VGNC:72244
Bos taurus EPHB6 VGNC VGNC:107222
Rattus norvegicus EPHB6 RGD RGD:1306163
Mus musculus EPHB6 MGD MGI:1096338
Canis familiaris EPHB6 VGNC VGNC:40414
Macaca fascicularis EPHB6 NCBI
Others EPHB6 NCBI