1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. Ephrin/Eph Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. Eph Receptors
  5. EphB6
  6. EphB6 Protein, Human (HEK293)

EphB6 Protein, Human (HEK293)

Cat. No.: HY-P75751
Handling Instructions

EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with tag free. The total length of EphB6 Protein, Human (HEK293) is 563 a.a., with molecular weight of ~72 kDa.

For research use only. We do not sell to patients.

Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with tag free. The total length of EphB6 Protein, Human (HEK293) is 563 a.a., with molecular weight of ~72 kDa.

Background

EphB6, a kinase-defective receptor specializing in interactions with members of the ephrin-B family, serves as a binding partner for both ephrin-B1 and ephrin-B2. This receptor intricately regulates cell adhesion and migration, demonstrating a nuanced impact with both positive and negative effects upon stimulation by ephrin-B2. Particularly, EphB6 displays the ability to inhibit JNK activation and attenuate T-cell receptor-induced IL-2 secretion and CD25 expression when prompted by ephrin-B2. Noteworthy interactions include associations with CBL and EPHB1, as well as a ligand-independent interaction with FYN, unveiling the multifaceted nature of EphB6 in cellular signaling pathways.

Species

Human

Source

HEK293

Tag

Tag Free

Accession

O15197 (L32-S594)

Gene ID
Molecular Construction
N-term
EphB6 (L32-S594)
Accession # O15197
C-term
Synonyms
Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6; EPHB6
Molecular Weight

Approximately 72 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
EphB6 Protein, Human (HEK293)
Cat. No.:
HY-P75751
Quantity:
MCE Japan Authorized Agent: