Tnfrsf1b - tumor necrosis factor receptor superfamily, member 1b Gene

Also Known as p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21938

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF Receptor Superfamily member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf1b Products (1)

mRNA Protein Name
NM_011610.3 NP_035740.2 tumor necrosis factor receptor superfamily member 1B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10747083 MGI
enables tumor necrosis factor receptor activity IPI
IPI: Inferred from physical interaction
1645445 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within RNA destabilization IMP
IMP: Inferred from mutant phenotype
11588035 MGI
involved in aortic valve development IGI
IGI: Inferred from genetic interaction
26491108 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9551933 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
7990930 MGI
involved in glial cell-neuron signaling IMP
IMP: Inferred from mutant phenotype
27147664 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
9551933 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
17242187 MGI
involved in negative regulation of cardiac muscle hypertrophy IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in negative regulation of extracellular matrix constituent secretion IGI
IGI: Inferred from genetic interaction
26491108 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
11588035 MGI
involved in negative regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
27147664 MGI
involved in positive regulation of apoptotic process involved in morphogenesis IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
27147664 MGI
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
27147664 MGI
involved in pulmonary valve development IGI
IGI: Inferred from genetic interaction
26491108 MGI
involved in regulation of T cell cytokine production IMP
IMP: Inferred from mutant phenotype
28052249 MGI
involved in regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
28052249 MGI
involved in regulation of cytokine production involved in immune response IGI
IGI: Inferred from genetic interaction
28052249 MGI
involved in regulation of myelination IGI
IGI: Inferred from genetic interaction
28052249 MGI
involved in regulation of neuroinflammatory response IGI
IGI: Inferred from genetic interaction
28052249 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in membrane IDA
IDA: Inferred from direct assay
10747083 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
17010968 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 1B

  • TNF receptor beta chain

  • TNF-RII

  • TNFR-II

  • p75 TNFR

  • p80 TNF-alpha receptor

  • tumor necrosis factor receptor 2

  • tumor necrosis factor receptor type II

Recombinant Tnfrsf1b Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70516 TNF RII/TNFRSF1B Protein, Mouse (HEK293, His) P25119/NP_035740.2 (V23-G258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72420 TNF RII/TNFRSF1B Protein, Mouse (HEK293, His-Avi) Q545P4 (V23-G258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76108 TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc) P25119 (M1-G258) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P990994 Emunkitug Inhibitor 99.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14811 TNFRSF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174515 Human TNFRSF1B mRNA / Unkown
HY-RS17435 Tnfrsf1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23891 Tnfrsf1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P99782 Opinercept Inhibitor / Unkown
HY-P991403 BC011 Inhibitor / Unkown
HY-P991680 Elipunercept / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf1b NCBI NCBI:7133