Numbl - NUMB-like, endocytic adaptor protein Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 292732

Summary

Involved in positive regulation of dendrite morphogenesis. Predicted to be active in cytoplasm. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Numbl Products (2)

mRNA	Protein	Name
NM_001033888.2	NP_001029060.2	numb-like protein isoform 2
NM_001398697.1	NP_001385626.1	numb-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18299187	RGD

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	16394100	RGD
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	16394100	RGD
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	16394100	RGD

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16394100	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16394100	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
numb-like protein	numb homolog-like

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS09682	NUMBL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22696	Numbl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29210	Numbl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Numbl	NCBI	NCBI:9253